Metabolic Reset

MOTS-c activates AMPK from inside the mitochondria, Berberine activates it from the cell membrane. This is dual-pathway AMPK activation: the body's primary metabolic regulator turned on from two complementary angles simultaneously. Berberine also independently improves insulin sensitivity and is Thorne's #2 best seller, with clinical evidence that directly mirrors what MOTS-c and Tesamorelin are trying to achieve.

Visceral fat secretes inflammatory cytokines (IL-6, TNF-α) that worsen insulin resistance and blunt fat loss. Super EPA suppresses these fat-derived inflammatory signals, creating a cleaner metabolic environment for Tesamorelin's visceral fat reduction. EPA also supports healthy lipid metabolism, which is important as Tesamorelin shifts the body's fat profile during the protocol.

Both peptides improve insulin sensitivity through different mechanisms. Chromium Picolinate enhances insulin receptor sensitivity at the cellular level, adding a third angle of metabolic improvement. It directs glucose toward muscle cells for energy rather than fat cells for storage, amplifying the metabolic shift both peptides drive.

As these peptides ramp up fat oxidation and cellular energy production, demand for B vitamin cofactors increases proportionally. B2 and B3 are direct participants in the electron transport chain that converts fat into ATP. Basic B Complex ensures the cellular machinery running faster as a result of the protocol has all the cofactors it needs to operate at full capacity.

MOTS-c activates mitochondrial metabolism, CoQ10 is the mobile electron carrier that makes that metabolism possible. As MOTS-c increases mitochondrial output, CoQ10 demand rises in proportion. Supplementing CoQ10 ensures the mitochondria can fully utilize the increased metabolic activity MOTS-c drives, preventing it from becoming the limiting factor in cellular energy production.